Hepatitis B

The background of Hepatitis B

Liver diseases remain a serious social, economic and epidemiological health problem all over the world. Chronic viral Hepatitis (CVH) and liver cirrhosis take a significant place in the disease structure of the digestive system. According to the WHO there are more than 2 billion people having evidence of current or completed infection with the virus of Hepatitis B, where over 350 million are currently infected; every year about 2 million people die from pathology associated with viral Hepatitis B. About 500 million people worldwide suffer from chronic HCV infection. In Europe, the highest incidence of chronic Hepatitis is in Moldova, Hungary, Italy, Germany and France, where the mortality from these diseases ranges from 32,7 (France) to the 127.4 (Moldova) per 100,000 population. According to our data, in Leningrad – St. Petersburg a long-term dynamics of recorded incidence increases from 1.0 in 1962, to a record in 1995 to 29.3 per 100,000 population. The incidence rate in the 1990-ies caused mainly because of viral Hepatitis B and viral Hepatitis C (V. G. Radchenko, et al., 2000)

Experts predict that in 10-20 years along with increase in the world, for example, the quantity of HCV patients in cirrhotic stage, the mortality from complications of portal hypertension, the proportion of hepatocellular carcinoma and the necessity for liver transplantation will increase (A. G. Rakhmanova, et al., 2006; V. V. Stelmach, et al., 2007). The increased importance of chronic Hepatitis B and C (CHB, CHC) in the territory of Russia is due to the high level of morbidity, the rising number of virus carriers (in Russia from 3 to 5 million people are carriers of Hepatitis viruses B or C), the changes in the structure of pathogen transmission (infection with the injections of drugs and with active sexual life), and also a predominance of young adults (A. G. Rakhmanova, et al., 2006; D. I. Shakhgildyan, 2001).

Among the immune mechanisms in the pathogenesis of viral Hepatitis the lack of alpha-interferon production has the important part, which reduces its antiviral action and activation of viral replication (A. A. Yakovlev et al., 2006).

The treatment of viral Hepatitis remains quite complicated and not completely solved problem, especially for chronic Hepatitis B and C. The actual necessity of antiviral therapy in the various stages of VH is certain: in acute VHC the chronic process is prevented, in chronic VHC – cirrhotic phase is under formation, the cirrhosis - its decompensation, the development of hepatocellular carcinoma (HCC).

Ask your gynecologist if he (she) has an experience in treatment of human papillomavirus infection to the complete removal of human papilloma virus from the body?