The available treatment ways of Hepatitis B
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In the treatment of viral Hepatitis (VH) AVM should act in several directions: to prevent the infection of new cells in the body and block the replication of the virus. The treatment of chronic HV (CHV), including the prevalence and progression of many forms of these diseases is one of the key problems in modern hepatology. The application of etiotropic therapy allowed not only to stop the progression of the disease in significant number of patients, but in some cases to achieve the complete cure.
The main indication for the use of AVM at any stage of the disease is the active replication of Hepatitis viruses, which are the markers for:
All antiviral CM (chemical medicines) used to treat the HV, belong to 3 main groups. Antiviral CM are used in the treatment of acute and chronic forms of HV. The simultaneous combined or sequential therapy drugs with three mentioned groups is appropriate. It is prospectively to use continuously for 2-3 months the two reverse transcriptase inhibitors and protease inhibitors in protracted course of acute Hepatitis, and in chronic Hepatitis – for 6-12 months depending on the nature of the activity, the extent of viraemia and the immune response.
The options of specific therapy can be an immunoglobulin with a high titer of anti HBs and recombinant vaccine against Hepatitis B. It is appropriate to use the interferons or their inducers in combination with antiviral CM.
The main groups of CM for the treatment of Hepatitis
Group 1 – the inhibitors of reverse transcriptase (RT) these medicinal substances, penetrating into the cell, inhibit the synthesis of DNA or RNA, replacing the natural nucleosides during the synthesis. The drugs of this group are divided into 3 subgroups:
Inhibitors of reverse transcriptase Analogues of nucleosides Didanosine (videx), ddI The greatest efficiency in HBV has lamivudine, AZT and famciclovir, in HCV – ribovirin, AZT. 1. Nucleotide analogues 2. Non-nucleoside analogues
Inhibitors of reverse transcriptase
Analogues of nucleosides
Didanosine (videx), ddI
The greatest efficiency in HBV has lamivudine, AZT and famciclovir, in HCV – ribovirin, AZT.
1. Nucleotide analogues
2. Non-nucleoside analogues
Group 2 - protease Inhibitors
Group 3 - Analogues of pyrophosphate
Analogues of pyrophosphate. In the cells under the influence of zymes they are phosphorylated to the active forms. The analogues of pyrophosphate have an inhibitory effect on the virus-specific enzymes, thereby blocking the synthesis of viral DNA and disrupting the replication of the virus.
The results of antiviral therapy cannot be considered satisfactory yet. Its effectiveness depends on the genotypes (and subtypes) of HCV, the selection of mutant strains of HBV, the level of viral RNA/DNA, the activity of the inflammatory process in the liver. The interferonotherapy is an expensive one, some patients have side effects and the formation of antibodies against IFN, which reduce the effectiveness of treatment. There are contraindications to interferon, in particular drug addiction. The questions about the efficiency increase of the interferonotherapy are still open (V. K. Kozlov et al., 2004). In this regard, the criteria of careful patients selection for enhancing the drugs effectiveness are necessary.
Ask your gynecologist if he (she) has an experience in treatment of human papillomavirus infection to the complete removal of human papilloma virus from the body?
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